ONE MORE PIECE OF THE PUZZLE REVISITED

Flexeril.

Who knew?

I got an email from Tonix Pharmaceuticals and they offered me the opportunity to interview the doctor that is the head of the pharmaceutical company and I could post the interview on my blog. This is an exciting opportunity for me. I really have looked at this trial. When I went for a clinical trial here in Las Vegas I asked if it was the TNX102 trial. If it had been, I would have jumped at the opportunity. 

I am reposting this and look forward to the interview with the doctor. 

Tonix Pharmaceuticals is starting Phase 2 clinical trials for their form of a very low dose cyclobenzaprine called TNX102 SL. It targets pain and the inability to get restoration from sleep...well, because we don't. You can't get something from something you don't do. It seems that the sublingual form is rapidly absorbed by the bloodstream and is rapidly excreted from the system.

Sounds like a win-win.

This study has approximately 120 patients taking either a tab or placebo at bedtime for twelve weeks and then measuring the change in pain intensity. The first phase of the trial has already been concluded with a reduction of pain, pain sensitivity, fatigue and mood. The study chair for this trial is Dr. Daniel Clauw, Professor of Anesthesiology, Medicine and Psychiatry and Director of the Chronic Pain and Fatigue Research Center at the University of Michigan. 

Tonix calls this protocol BESTFIT. BESTFIT stands for BEdtime, Sublingual, Tnx102sl, as Fibromyalgia, Intervention Therapy. Cute, huh? 

Cyclobenzaprine is an FDA approved drug that treats muscle spasms that is associated with musculoskeletal conditions. It's been prescribed off label as a sleep aid. What I didn't know is that there isn't any benefit with this drug after two to three weeks. Actually, what is said was "the evidence of effectiveness for prolonged use is not available." Everything I've read says that this drug should not be used long term.

??????

Pain managers have been giving it out and for much longer than two to three weeks. 

There are not many treatment plans for us out there. The ones that are there have some side effects that make the treatment worse than the affliction! Add to the mix that the treatments don't work for all of us. 

This study is being conducted at approximately 15 sites throughout the U.S. I can't wait to see the outcome but the initial results were promising.

Like I always say.

It can't come soon enough.

We watch and wait....

again.

Until we find the missing piece of the puzzle.

THE FIBROMYALGIA SERIES PART A

As we keep saying, 

until we are blue in the face.......

A - is for this is not all in our head! Even though research has proven it and medical journals have validated us there are still physicians who think this is all in our heads. It's demeaning and infuriating and it causes torment to those who have to go from doctor to doctor to find one that will believe that we're hurting and there is a reason.

A - is for the anguish this causes and......

A - is for the arrogance of some doctors and you'd like to slap them silly for callously dismissing the symptoms we have all because they can't find the time to help you with management.

A - is for advocate. There is no if, and, or but about it. We must be our own advocate. We need to arm ourselves with as much knowledge as we can. We need to watch what is prescribed and learn about our condition and how to manage it.  If we don't, no one will. The medical community is full of naysayers and doctors that haven't got the time for us. 

A - is for assertive. Yes, we need to have a voice and use it for what we need and expect from those who treat us. We should never walk out of an office in tears. We should never be confused by instructions or treatments that don't make any sense. When we find our voice we also find our confidence. Never be afraid to stand up for what you believe.

A - is for advice. Everyone has advice and you'll get a ton of it. People can be well meaning but this isn't just tired. This isn't just, "well I have aches and pains too." Everyone has someone who has someone who knows someone who has Fibromyalgia. Again, I'm sure they are well intentioned but there is advice galore out there. If you just take more magnesium it will help you.........sometimes it's just better to smile and say thank you.

A - is for appalling. There are sites that are full of the latest "cure." For $49.95 there is a supplement that will be the answer to all your prayers. These sites prey on our pain, fatigue and desire to find anything that can help us resume our life. There are snake oil salesman disguised as physicians that will promise to cure you if you just sign up for their protocol. There are people that will take advantage of the misery of others. Do a lot of research before you succumb to herbal remedies, vitamin or IV protocols or anything that promises you a cure. Some can be dangerous, let alone extremely expensive. Be careful.

A - is for agony.  Chronic illness takes a toll on your life. There is the physical agony and then there is the emotional agony. I don't know which one is worse. 

A - is for acknowledge. I have to acknowledge that this is "what it is." Why I still struggle with denial is beyond me. I think it's those days that I feel like I can leap tall buildings in a single bound. 

A - is for anxiety. Every single time, I mean every single time a new symptom pops up....

which brings me to.........

alarmed...............

and..........

waiting again for..........

something that will.........

alleviate all of this...........

( and this one is shorter because there is another A in Fibromyalgia!!)

THERMAL THERAPY..... OK, TAKE A HOT BATH

Now, I've read it all.

I don't know whether to laugh or cry.

We're back to mud.

I love going to the spa. It just feels good to get pampered every now and then. If we talk about now, I don't love massage anymore. Touch, especially touch that rearranges tender points, is not a good thing. 

It hurts like hell.

Now it seems that mud-bath therapy and balneotherapy (bath therapy) has hit the scientific pages regarding Fibromyalgia. For two weeks the subjects received "thermal therapy" (OK, a bath or a mud bath) for six days a week. 21 got a mud bath and 20 got a hot bath. Most of the patients reported a reduction in pain.

WELL, OF COURSE THEY DID.

Who hasn't felt better after a hot bath? My daughter has stories galore. Anything that went wrong.....get in the bath. As far as I'm concerned, a hot bath helps everything. You just feel better. I only see an eensie-weensie problem.

I can't live in the bathtub.

My goodness, who gets grants for this????

And, how can I get in on it?

There are studies about moderate drinking helping Fibromyalgia symptoms, now mud baths. Like I've said, if you're half lit of course you're not going to be in as much pain. There is the obligatory disclaimer about not drinking with certain medications, thank goodness. The same premise applies here. Who wouldn't feel better after a mud bath or a hot bath?

I find that when I get in the tub of swirling water at night it helps me relax. I take a muscle relaxer and take a good book, my diet coke and I light some aromatherapy candles and try to keep my muscles from going into painful spasms. It's one of those simple pleasures that, for just a few moments when I close my eyes, put me on a beautiful, verdant tropical island far away from the barren wasteland of Fibromyalgia. 

I love that part of the evening. There is one slight problem with a jetted tub and I cannot stress what I am about to tell you enough. Never, and let me say it once again, never put even a little bit of bubble bath in a jetted tub. Then after you've been dumb enough to do that, never lay back and close your eyes and surrender yourself to blissful meditation.  First of all, Philosophy's Amazing Grace bubble bath in your nostrils is vile. Second of all, it makes a TON of bubbles. It takes forever to get rid of the bubbles and the serenity of the bath will be replaced by the irritation of cleaning up bubbles.

OK, any followers that are doctors?? I have a wonderful idea for a study. We need to take 50 women who have Fibromyalgia. I'll leave the weeding out the candidates to the doctors. The control group will have a yummy, moist, chocolate filled, chocolate cake and the placebo group will receive edamame. The trick is to have each group watch each other eat. Then we report which group felt better after eating. (note: we do not weigh the control group after the study.) Let's name it "the chocolate cake hypothesis."

I think that would qualify as a scientific study.

When does common sense get into scientific publications?

Will insurance cover spa visits?

I do have so say one thing.

In some respects, I do like this study......

WHAT CAME FIRST, THE THYROID OR THE FIBRO?

Oh yay!

Another cure!!

Never mind the research.

Everyone else has been wrong.

It seems that everyone else has been misguided and the cure for Fibromyalgia has been right under our noses all this time.

It's your thyroid that causes the Fibromyalgia.

Sounds simple, huh?

I will agree that a lot of the symptoms sound the same but, at the same time, managing one does not automatically mean the cure of the other. The interesting part? The irrefutable evidence is currently on a website that is offline. 

Hmmmm.......

My doctor gets it. He knows there is a difference between normal and optimum. I don't feel well just being barely normal (OK, don't even go there!!!). I also need T3 and T4. I can't take levothyroxine alone, it just doesn't work for me. Getting my levels in check took some doing but now they seem to be where they need to be. 

I think it's interesting that that a lot of these symptoms are the same. I don't mean to sound flippant. There are a lot of issues with our body and the thyroid may just be one of them. The HPA axis dysfunction has long been a favorite theory of mine. I just think it's suspect when you take the same symptoms and point them to a simple fix.

Don't you think researchers have thought of this?

Maybe there is a problem with the thyroid due to low body temperature and basal metabolism that is common in Fibromyalgia patients, I don't know. Maybe some patients who were diagnosed with Fibromyalgia were actually severely hypothyroid. Maybe it is a problem but, right now, we just don't know. It's a shame that promising studies set themselves up for ridicule.

Why can't they just say, "another piece of the puzzle found."

Or, "study looks promising,

But, no......

Everyone else is stupid

And the cure was right under their noses.

So far, no one has been cured of Fibromyalgia,

But we can!!

(oops, the website with the proof is gone)

Is there any reason this shouldn't be suspect?

The thyroid science study link

IS THE F.D.A. ON D.R.U.G.S UPDATE

Yes, Virginia....

There is a Santa Claus.

All it takes is a little pressure from the Attorney Generals from 28 states and, guess what? 

VOILA!

Now maybe, just maybe the F.D.A. will rethink their approval of Zohydro. 

Believe me, I am not against pain medication. I need it to control the constant pain that I live with, BUT, I keep a tight control on the medication. These drugs, even in low doses, are very powerful and they need to be monitored. I've seen what drugs can do and it isn't pretty. You can take them and not wake up. 

The letter from the attorney generals have asked for the revocation of the approval or to make it conditional and the company must reformulate the product so that it is more difficult to abuse.

What I didn't know?

Zohydro is five to ten times more powerful than the currently available hydrocodone that's on the market. WOW! To my mind? These pills shouldn't be available to everyone. It should be for terminal pain patients. If you're walking around, you shouldn't need Zohydro. It's that simple. 

The company that makes Zohydro declined to comment but the FDA representative said they are reviewing the letter.

Again, pain medication is necessary.

I believe that.

In responsible hands they make one able to enjoy life.

But you don't need an Zohydro if you got a tooth pulled.

PRESTO, CHANGO, SWITCHEROO

How dare they?

We should be up in arms.

Is anything real anymore?

I was reading an article about herbal supplements. A lot of us use them in conjunction with conventional medicine for relief from anything from colds to pain. And everything in-between. I was appalled to read an article where the DNA was tested and the herb was nowhere to be found in the bottles and if it was a highly diluted form.

What?

It seems that greed has struck again.

This is a five BILLION dollar a year industry and what people have been buying is little more than powdered rice and weeds. Yes, it is unproven that these supplements can cure what ails us according to the FDA, but,  HOW DARE THEY???

Canadian researchers tested 44 bottles of supplements sold by 12 companies. If there was the actual herb in there it was often diluted or replaced with fillers like rice, soybean or wheat. 

Where is the oversight of this industry?

If you've used echinacea, St. John's Wort or ginkgo biloba the odds would say that you probably didn't get what you thought you were buying. Or there was a highly diluted substance being passed off as the real thing.

Just terrible.

How do we really know what we are purchasing?

I guess we don't.

Well, unless we run a lab.

I just have a eensie, weensie criticism of the article.

RELEASE THE DAMN NAMES OF THE COMPANIES!!!

HERE'S THE LINK TO THE ARTICLE IN THE NY TIMES.

IT'S ALIVE!!

Sorry in advance.

This is simply shocking!

I thought it was fitting to wind up October with this post. Call me old fashioned but I really believe there are things you shouldn't mess with and randomly shocking your brain is one of them. I know there are times for this protocol; actually they call it brain stimulation, and it can be used for major depression and seizure therapy.

How would you like to be in that clinical trial?

Just imagine......you can stimulate your brain and have no pain. Whoa.....I should be in advertising.....stimulate your brain and have no pain. What a campaign.....there I go again.... it just never ends......

It's actually called High Definition transcranial direct current stimulation or HD-tDCS. You put a few electrodes on your scalp and voila!  A few electric shocks later.....your brain releases opioid like painkillers.

Sounds simple......

Wait...it's a 20 minutes session and it said it reduces the pain perception. Hmmmm.....I may be one of those people that are sensitive to wording. Must be from years of reading the fine print in contracts. 

Granted the dose of electricity is very small compared to the doses used for clinical depression or seizures. OK, what I want to know is how they figured that out. How many brains did they have to melt to figure it out? 

Anyway.....the kicker?

The researchers don't know why this works. 

That sentence speaks for itself.

Happy Halloween!!!!

I AIN'T TALKIN' BOUT THE CEREAL

On the street it's called Special K.

It's a horse tranquilizer in veterinary medicine.

It's a money maker for chronic pain.

I get it. Sometimes the pain gets too much and we're at the end of our rope. We want to reach for something, anything that can promise relief from the pain. We just need to be careful that we are not reaching for something that can do more harm than good.

Ketamine infusion therapy is big business in the chronic pain world. A single infusion can cost $2000 a treatment and, believe me, the recommended course is definitely NOT  a single treatment.

Ketamine is used to produce a loss of conscienceness. It's used as a general anesthetic but because of the hallucinations that it can cause it's not the primary choice. It is used by compounding pharmacies as a cream with lidocaine and ketoprophan as a topical pain reliever.

This drug is no joke.

It increases your heart rate and blood pressure. It can cause hallucinations, dizziness, nausea, blurred vision, nightmares, memory problems and if used long term liver abnormalities. It induces a state of disassociative anesthesia. 

Scary.

Years ago a study was done with 34 Fibromyalgia patients. They got a low dose Ketamine infusion followed by a dextromethorphan treatment. 19 responded to neither drug, 10 were favorable to both, 3 were helped by the ketamine but not the dextromathorphan  and 2 were helped by the dextromethorphan but not the ketamine. Link to study

There are sites offering Ketamine therapy. Everything about Ketamine states you should be monitored closely due to adverse effects but there are places giving you this therapy on an outpatient basis. Now they do tell you to stay with someone so if you have any ill effects they can get you to a doctor. Gee, that's comforting. I may have someone watching me who hasn't got a medical license and they are the ones to watch for adverse effects?  They also tell you that it may not work and this is a totally elective therapy. 

It gets even better. There is a Ketamine Coma Therapy being offered in other countries. It is given in extremely high doses so that a coma is induced. This, obviously, is not approved by the FDA. 

Back to the infusions......they tell you that if you want it YOU NEED TO SATISFY YOURSELF by the research YOU DO through search engines. In other words, we just give it to you and if there's a problem you should have done better research. To me, that borders on negligence. We need qualified people that will tell us the realities of medicine and what it can do. We shouldn't be the ones doing the search and then telling the doctor it's ok. 

It also tells you tough noogies because you may elect to proceed knowing it may have no benefit. They also tell you the greater number of infusions you have the greater the benefit. 

At 2 grand a pop that sounds like double speak to me.

Just keep paying and pray it helps.

I'm not saying it may not help some people. It might. 

Everything in me shouts NO.

Everything I read about this drug screams "dangerous in the wrong hands."

It's a street drug that packs a wallop.

It can kill you.

Please be very careful if you are going through with this therapy.

You need to be watched carefully.

Personally?

I wouldn't do it.

I think it needs more study. 

ONE MORE PIECE OF THE PUZZLE

Flexeril.

Who knew?

Tonix Pharmaceuticals is starting Phase 2 clinical trials for their form of a very low dose cyclobenzaprine called TNX102 SL. It targets pain and the inability to get restoration from sleep...well, because we don't. You can't get something from something you don't do. It seems that the sublingual form is rapidly absorbed by the bloodstream and is rapidly excreted from the system.

Sounds like a win-win.

This study has approximately 120 patients taking either a tab or placebo at bedtime for twelve weeks and then measuring the change in pain intensity. The first phase of the trial has already been concluded with a reduction of pain, pain sensitivity, fatigue and mood. The study chair for this trial is Dr. Daniel Clauw, Professor of Anesthesiology, Medicine and Psychiatry and Director of the Chronic Pain and Fatigue Research Center at the University of Michigan. 

Tonix calls this protocol BESTFIT. BESTFIT stands for BEdtime, Sublingual, Tnx102sl, as Fibromyalgia, Intervention Therapy. Cute, huh? 

Cyclobenzaprine is an FDA approved drug that treats muscle spasms that is associated with musculoskelatal conditions. It's been prescribed off label as a sleep aid. What I didn't know is that there isn't any benefit with this drug after two to three weeks. Actually, what is said was "the evidence of effectiveness for prolonged use is not available." Everything I've read says that this drug should not be used long term.

??????

Pain managers have been giving it out and for much longer than two to three weeks. 

There are not many treatment plans for us out there. The ones that are there have some side effects that make the treatment worse than the affliction! Add to the mix that the treatments don't work for all of us. 

This study is being conducted at approximately 15 sites throughout the U.S. I can't wait to see the outcome but the initial results were promising.

Like I always say.

It can't come soon enough.

We watch and wait....

again.

Until we find the missing piece of the puzzle.

IT'S CALLED CLASS AND COURTESY

They've just released a major break though in the fight.

They're besieged by requests for comments.

They graciously responded.

I guess I shouldn't say "they."  After writing the post about the breakthrough I decided to go to the website and ask a couple of questions. 

I identified myself and posed my questions. I mentioned that I wrote a blog and tried to keep up on the latest research. I then signed off respectfully with my name and the name of my blog. 

I hoped I'd hear but I really didn't think that I would.

I was wrong.

The reason I didn't hold out hope was I tried this before. Not with this company but with the writers of a Fibromyalgia blog. I reached out and was basically told that since I wasn't published they wouldn't be responding. 

Isn't that a sweet thing to do? 

When I reached out to this company I still had visions of these research scientists and doctors not wanting to have anything to do with a lowly blog writer. What I encountered was a heartfelt email. Wrong. Make that two emails. 

One email was documents that I could feel free to share and the other was a response to my questions and a wish for continued well being. Yes, they have tons of people writing to them, sharing their stories. Are they annoyed by this? No. They are gracious and willing to share what they know. They honestly want to make the suffering of Fibromyalgia and chronic pain go away and work tirelessly to that end goal.

I truly believe they're on to something. I didn't realize that trauma can cause an increase in the nerve endings. Genetics can also be involved.  

What do I like the most?

The fact that he wanted Fibromyalgia sufferers to take comfort in one fact.

This isn't all in our heads.

It's real.

LINKS TO ARTICLES 

LINKS TO ARTICLES

IT'S ALL IN THE PALM OF MY HAND

I keep reading the study.

Over and over again.

Is it that simple?

Can it be that simple?

I have questions.

It seems that the nerve endings in the AV shunts in the palms of our hands hold the secret of Fibromyalgia. The AV stands for arteriole-venule which, up until now, just regulated blood flow. Now it seems that an over abundance of these nerve fibers are the source of our pain.

It's possible.

Anything is possible.

But this brings questions. Does that mean that these excess nerve fibers were a genetic anomaly? If that is the case then are they able to remain dormant and then be triggered by an illness or trauma?

Most of us can pinpoint when the pain started. For me, it was trauma. I don't understand....did the trauma cause my palms to grow excess nerve fibers or were they there and dormant. Well, wait....if they were dormant I wouldn't be able to feel anything, would I?

On the other side.....I can always feel a flare coming on because it starts with my hands. 

They summarize that the blood flow is responsible for the muscular achiness and pain. The fatigue is from a build up of lactic acid and inflammation. It sounds like that triggers the brain going a little haywire.  These shunts could be keeping blood flow from reaching deep into the muscles. As far as the brain going haywire....we all know what happens then.....

We can't sleep.

The interesting thing, to me, is that these shunts are critical for thermal regulation and our metabolism. It's that why some of us have heat or cold intolerance??  As far as our metabolism goes......could it be why this is so closely intertwined with our thyroid?

If this is the case why do some medications work for some people and not others? What about all the symptoms. Can it all be due to excess sensory fibers in our hands??

I'm thinking about this.

But I still have questions.

I think this bears watching.....

but now, when I feel a flare coming on......

And I'm rubbing my hands.......

I'll take notice.

WHAT'S NEW ON THE HORIZON?

Ok.

I like this one.

And it's been used in Europe for years.

Flupirtine. Interesting sounding name.....who names these things?? Anything starting with a "f-l-u-p" sounds kind of dorky to me, but hey, what do I know?

But, again, I digress.

I do that a lot.

This is an exciting new drug on the horizon.  I'll include the link to the articles at the bottom of the post. I've never heard of it and it sounds promising. Anyway, this drug is neither an opioid or an non-steroidal anti-inflammatory drug (NSAID). It has properties of being both an analgesic and a muscle relaxant. 

It has been used in Europe for the last 25 years for treatment of pain after surgery, trauma, dental work, muscle spasms, cancer and degenerative muscle diseases. The FDA graciously granted phase II clinical trials to be conducted for the treatment of Fibromyalgia.

This has been used in Europe for 25 years?

For extreme pain and muscle diseases??

Why don't we have it here?

The side effects are minimal and there isn't the dependence issue that your body has with an opioid. The NSAIDS have been associated with gastrointestinal issues and, again, this isn't an issue with flupirtine.

It sounds like a miracle drug.

But, believe it or not, it hasn't been introduced in the U.S. for any reason.

I can't wait to see more about this.

25 years........we've never had this.

Why???

Information on Flupirtine

THE CALAMARI SUBSTITUTION

While I love calamari rings, the tentacles,

or testicles (as my daughter would say) are not my favorite.

What does this have to do with anything??

I was just stumbling around this morning (what else is new?) and trying to see if anything was new out on the clinical trial horizon. What I found was staggering (and yes, I do that too). I was looking for pictures on Google images and saw a cool picture of hands. I started looking at some of the links and found out about the Calmere Therapy protocol.

What would I give to be off medication and relatively pain free?

Everything I own.

The clinical trial by the University of Wisconsin has finalized. The final processing was done on September 30th, so we should be able to see the results any time now. I'm putting all sorts of links in this post because this is the first thing that looks like it may work. 

Basically, what it does is take the pain signals and sends an artificial signal that says "no pain" to the brain.

I think I missed it because it has been filed under chronic neuropathic pain and indicated for cancer patients with chemo induced neuropathy. As you continue down the list though, it is for low back pain and neuromuscular diseases. Yep, that's us!!!!

During the treatment patients usually experience no pain and the duration that it lasts is determined on the underlying cause and intensity of the pain. You get treatment one treatment a day for two weeks and then booster treatments as needed. It's non-invasive and, obviously, drug free.

It looks like a giant Tens unit but it's faster, stronger and more effective. The Scrambler Therapy recorded at 59% reduction in pain. Let me tell you, if something reduced my pain by almost 60%......I could be functional again. 

The Mayo Clinic is conducting trials using the Scrambler Therapy as well. There are locations across the country using this protocol. 

I just think this is kind of interesting.....

At least it woke me up this morning........

Caffeine and getting scrambled.........

Works for me!

Just as an FYI.....when I spell checked neuromuscular ....it came up numskull.

How fitting is that??????

LOOK INTO MY EYES

You can tell a great deal about a person by their eyes.

Can you really tell when they're sick?

The study of iridology is interesting. Can you really tell how someone is feeling by their eyes? Is the story of our genetic makeup told in our eyes? Alternative medicine finds it a viable form of medicine, however, the medical community has totally dismissed it as foolishness. 

So what is it?

Simply, it is that the colors and patterns of the iris of the eye can give information about your health. The charts tell what organs are healthy and which are inflamed or in distress. There are four different sub-types of personalities that have different challenges.

Neurogenic: The neurogenic type has a resilient nature. Neurogenics are hard workers with a natural drive. They need to learn how to relax. The central and autonomic nervous system can give them trouble. Yoga and Tai Chi is helpful. They should avoid stimulants like sugar, caffeine, coffee and junk food. They should keep the volume down and avoid excessive noise.

Connective Tissue: As the name implies, this subset has connective tissue issues and is prone to sprains, hernias and problems with the joints and ligaments. Yoga and Tai Chi is helpful. Connective Tissue personalities should avoid sugar, caffeine, coffee and other junk food. 

Poly glandular: The polyglandular type has problems with an imbalanced glandular system. The thyroid, parathyroid, gall bladder and other digestive problems can hound these personalities. Yoga and Tai Chi is helpful for these people. These people should avoid processed or refined foods. 

Anxiety Tetanic: This is the typical Type A personality. These personalities are prone to creating stress for themselves. They need to learn how to relax. They are prone to neuro-muscular disorders, TMJ and spinal trouble. They should avoid stimulants like coffee, sugar, processed and refined foods. Yoga and Tai Chi may be helpful.

Obviously, this isn't an in-depth look at iridology. It's just a quick overview of the different personality types and some of the challenges they face. From the little that I read, I don't have a lot of desire to investigate more. It doesn't make sense that every type should avoid processed and refined foods and stimulants and that every type is helped by Tai Chi and Yoga. 

I know that we would all try anything to cure what ails us. We would investigate every avenue. I just don't think this is the path that will lead us to health.

The size of my pupil can tell the health of my autonomic nervous system?

So, when you look into my pupils you can see my spine?

When I think about this I think of the snake in Disney's Jungle Book......

Trust in me.........